The Republican Party has made gains in the Senate and secured a majority for the first time in four years.
A third of the Senate’s 100 seats were up for grabs at this year’s elections, with 51 required for a majority.
The Democrats have been in control of the upper house of Congress for the last four years.
US election latest: Trump wins key battleground states
But the Republicans have wrestled control after making gains in elections overnight.
Independent candidate Bernie Sanders has been projected to win a fourth term representing Vermont.
Eight seats in the Senate are yet to be declared.
All 435 seats in the House of Representatives, the lower house, are also up for grabs.
Donald Trump is projected to win several key battleground states in the race to the White House, narrowing Kamala Harris’s path to victory.
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