Seven people have been killed and dozens more injured after a bus crash in Mississippi.

A six-year-old boy and his 16-year-old sister were among those who died when the bus overturned on a major motorway near Bovina in Warren County just before 1am on Saturday morning.

Pictures from the scene showed the extremely damaged red bus, with broken windows along one side. Some of the passenger’s belongings, including what looked like a pink coat, was seen hanging out the side of the bus.

Six of the passengers were pronounced dead at the scene on Interstate 20, according to the Mississippi Highway Patrol.

Another passenger died in hospital. A total of 37 people were taken to hospitals in Vicksburg and Jackson.

Warren County coroner Doug Huskey said most of the bus passengers were Latin American.

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No other vehicle is believed to have been involved.

“Anytime you have people injured or killed, it’s tragic but when you have a situation like this where you have multiple fatalities and multiple injuries, it makes it even worse,” Warren County sheriff Martin Pace told ABC.