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That moved the 32-year-old to 25 goals on the season to go with 75 assists, both career bests.
It marks the 15th time a blue-liner reached 100 points in a season in NHL history. Bobby Orr has the record with 139 points in 1970-71.
Karlsson, a two-time Norris Trophy winner (2012, 2015) for the league’s top defenseman, is the favorite to take home the award for a third time.
Reuters contributed to this report.