Pujols launched a slider from former teammate Johan Oviedo over the Big Mac Land sign in left field at Busch Stadium, his 22nd homer of the season. The solo drive in the fourth inning made it 1-all.
Pujols faced Oviedo for the first time and made the 24-year-old righty the 456th different pitcher he’s homered against.
The St. Louis star hadn’t homered in a week since hitting No. 699 and 700 at Dodger Stadium last Friday. Pujols had gone 10 at-bats without a home run after two starts and one pinch-hit appearance.
The Busch Stadium crowd gave the 42-year-old Pujols a long standing ovation before he came out of the Cardinals dugout to tip his cap for a curtain call.
Before the game, the slugger was recognized for hitting his 700th last week at Los Angeles. He was given a gold-plated, engraved bat by owner Bill DeWitt Jr., team president Bill DeWitt III and manager Oliver Marmol.
Pujols’ homer was his 55th against the Pirates, his third-most against any team, trailing Houston (70) and the Chicago Cubs (62).
Pujols is fourth on the career home run list behind Barry Bonds (762), Hank Aaron (755) and Babe Ruth (714).
The Associated Press contributed to this report.